If you are a guitarist ... the harmonica is an ideal 'second' instrument to explore because it has many many qualities you will be familiar with.
I am not talking about playing 'acoustic' harmonica, no, using a mic and going through an amp is what this topic is about.
Once you have learned where the notes are laid out on the diatonic harp, you'll upskill from playing traditional blues riffs to learning how to bend notes. Adam Gussow has great youtube lessons.

Then you'll find this little instrument can not only 'bend' notes like guitarists, it has 'attack', dynamics, nuance, vibrato, wahwah effect (mic in the hand technique), chords as well as single note playing.
Mic choice, use of effects and playing through different amps are all part of a harmonica players world much like a guitarist.

I am not sure I have covered everything, but....amplified blues harmonica is a beast worth exploring.